Enrichment analysis of the STAT1-centered network identified several pathways relevant to CHD, including the advanced glycation end-product receptor for advanced glycation end-products (AGE-RAGE) signaling pathway,[38] Mitogen-Activated Protein Kinase(MAPK) cascade, and Nuclear Factor kappa B (NF-κB) pathway. This evidence concerns the gene WNK2 and coronary artery disorder.