Activated STAT1 enters the nucleus and regulates the expression of several inflammation-related genes related to inflammation.[34] STAT1 promotes the recruitment of immune cells to damaged coronary artery walls, intensifying the inflammatory response and thereby influencing CHD progression.[32,35] Additionally, STAT1 modulates the function of immune cells such as macrophages and T lymphocytes, and their abnormal activation is closely associated with CHD development. The gene discussed is STAT1; the disease is coronary artery disorder.