In IVW algorithm, after removing confounding factors, 5 candidate genes were significantly causally associated with CHD, where qtl-a-ENSG00000141736 (ERBB2) (OR = 1.081, 95% confidence interval (CI) = 1.000–1.169, P = .049), eqtl-a-ENSG00000134242 (PTPN22) (OR = 1.104, 95% CI = 1.049–1.162, P < .001), eqtl-a-ENSG00000102755 (FLT1) (OR = 1.087, 95% CI = 1.024–1.155, P = .006), eqtl-a-ENSG00000005381 (Myeloperoxidase, MPO) (OR = 1.046, 95% CI = 1.009–1.085, P = .014), and eqtl-a-ENSG00000115415 (STAT1) (OR = 1.148, 95% CI = 1.041–1.265, P = .006), all were risk factors (Table 1). Here, ERBB2 is linked to coronary artery disorder.