CREB1 and gastric adenocarcinoma: For example, Cheng et al (2025) revealed that the lncRNA SNHG4 promotes GC progression by sponging miR-409-3p, thereby derepressing its target CREB1.[12] We further validated this inverse co-expression relationship between miR-409-3p and CREB1 in the TCGA-STAD cohort, lending functional credence to our genetic findings.