PTEN and gastric cancer: For instance, in acute promyelocytic leukemia and hepatocellular carcinoma, miR-382-5p promotes oncogenesis by targeting PTEN, thereby activating the PI3K/Akt signaling pathway.[23,24] Furthermore, in oral squamous cell carcinoma, cancer-associated fibroblast-derived exosomal miR-382-5p facilitates metastasis,[25] highlighting a potential paracrine mechanism that could be relevant to GC.