In contrast to its role in GC, miR-654-5p acts as a tumor suppressor in colorectal cancer (CRC), where its downregulation is associated with poor prognosis and it functions by targeting HAX-1.[28–30] It also shows oncogenic properties in oral squamous cell carcinoma via the Ras/MAPK pathway.[31] This functional dichotomy is likely governed by the distinct landscape of target genes expressed in different tissues. The gene discussed is HAX1; the disease is oral cavity squamous cell carcinoma.