CAMK2A and heart failure: CAMK2A, also known as CaMKIIα, represents the principal isoform of calcium/calmodulin-dependent protein kinase IIα, predominantly found in the brain with some presence in the heart.[48,49] While CaMKII has been implicated in various aspects of heart failure and arrhythmias, the specific roles of CaMKIIα isoforms in cardiac physiology remain unclear, highlighting the necessity for further research to delineate their impacts on cardiac development, function, and pathology.