In addition to impairing cell growth and slightly increasing apoptosis, palbociclib treatment caused more than a 10-fold increase in senescence-associated B-galactosidase levels, indicating the induction of cell senescence in t(8;21) AML.[19] Interestingly, the treatment caused a reduction in Enhancer of Zeste Homolog 2 transcript levels both in AML and ALL,[19,32] suggesting that it is unlikely to promote cellular quiescence.[35]. The gene discussed is EZH2; the disease is acute myeloid leukemia.