On the other hand, glyoxalase 1 (GLO1) is upregulated in chronic lymphoblastic leukemia and is associated with increased expression of CDK4.[45] Knockdown of CDK4 caused downregulation of GLO1, which is a rate-limiting enzyme of the glyoxalase system, and its overexpression is associated with multiple drug resistances in cancer. The gene discussed is CDK4; the disease is cancer.