Palbociclib also induces downregulation of the pathway involving homeobox A9 (HOXA9), PIM1 and B-cell lymphoma (Bcl-2)-associated death promoter (BAD), contributing to the sensitization of AML cells to cytarabine’s apoptotic induction and cytotoxicity.[22] Downregulation of HOXA9 expression resulted in a simultaneous decrease in the expression of the HOXA9-target gene PIM1, which led to the release of inhibition on the phosphorylation of BAD and promoted apoptosis. This evidence concerns the gene BCL2 and acute myeloid leukemia.