MAP2K7 and cancer: Nodakenin exerts anti-hepatocellular carcinoma effects by downregulating CXCL5 and inhibiting the ERK/MEK pathway, and also induces apoptosis and inhibits the proliferation of HeLa cells, indicating potential anticervical cancer activity.[33] Ammidin promotes autophagy and has shown promising anticancer and antidrug resistance properties in cervical cancer models.[34] However, there is a paucity of research on the role of these compounds in RA treatment, highlighting the need for further mechanistic studies on the pharmacological actions of other active ingredients in Duhuo.