Nodakenin exerts anti-hepatocellular carcinoma effects by downregulating CXCL5 and inhibiting the ERK/MEK pathway, and also induces apoptosis and inhibits the proliferation of HeLa cells, indicating potential anticervical cancer activity.[33] Ammidin promotes autophagy and has shown promising anticancer and antidrug resistance properties in cervical cancer models.[34] However, there is a paucity of research on the role of these compounds in RA treatment, highlighting the need for further mechanistic studies on the pharmacological actions of other active ingredients in Duhuo. This evidence concerns the gene CXCL5 and rheumatoid arthritis.