Fig. 8F reveals upregulated signaling in T1D through proteins and pathways linked to inflammation, immune modulation, and ECM remodeling, including GAP, VTN, TGFb, EGF, SPP1, PDGF, LAMININ, and COLLAGEN, suggesting structural changes and adaptive responses to tissue damage. This evidence concerns the gene TGFB1 and type 1 diabetes mellitus.