GATA3 and breast carcinoma: To explore whether our DNAzymes could knock down GATA3, we designed constructs targeting a GU junction in exon 6 of the GATA3 transcript (nucleotides 2490–2491) and transfected MCF7 breast cancer cells with Dz46, tC3, and tC3+ variants (Fig. 5d and Supplementary Fig. S9).