HCC is equivalent to the mammalian cleavage factor (mCF; with CPSF73, CPSF100, and symplekin) in the canonical machinery [12, 13], and CPSF73 is the endonuclease that catalyzes the cleavage reaction in both machineries [14, 15]. This evidence concerns the gene CPSF2 and hepatocellular carcinoma.