For this study, we only selected five well known cancer predisposition genes (ATM [12], BRCA1 [13], BRCA2 [14], CHEK2 [15], and TP53 [16]) and four putative candidate MM risk genes from prior studies, namely ARID1A [17], DIS3 [18], KDM1A [19], and USP45 [17]. The gene discussed is CHEK2; the disease is cancer.