Although genetic abnormalities - including chromosomal translocations such as t(11;14) and t(4;14), copy number aberrations and mutations in key driver genes such as TP53, KRAS, NRAS, DIS3 - are considered hallmark somatic events of these tumors [1, 2], relatively little is known about the germline components that may predispose individuals to increased risk of MM [3]. This evidence concerns the gene TP53 and Miyoshi myopathy.