Gene-wise carrier rates were similar across case datasets with the notable exception of TP53, BRCA2 and KDM1A. The TP53 carrier rate was 0.7% in the MMSEQ cases, who were selected for early onset MM or a history of familial cancer, while only 0.1% in the UKB MM cases. The gene discussed is KDM1A; the disease is hereditary cancer.