The sample sizes are as follows: Klotho (High: n = 603, Low: n = 605), age (< 65 years: n = 801, ≥ 65 years: n = 407), renal function by creatinine level (Cr < 133 μmol/L: n = 1165, Cr ≥ 133 μmol/L: n = 43), and diabetes status (No diabetes: n = 947, Diabetes: n = 210, Borderline: n = 51). This evidence concerns the gene KL and diabetes mellitus.