This environment is characterized mainly by reduced concentrations of IL-10 and IGF-1, and increased concentrations of GDF-8, leptin, IL-1, IL-6, and TNF-α, thereby increasing inflammation in fat and muscle [72] and increasing osteoclast activation by enhancing RANKL expression in osteoblasts, aggravating osteoporosis [73]. The gene discussed is IL6; the disease is osteoporosis.