AKT1 and non-Hodgkin lymphoma: This pathway is most frequently aberrantly activated in human malignancies and their precursor lesions,243 spanning breast,245 laryngeal,246 colorectal,247 cervical,248 and non-Hodgkin lymphoma.249 Pathogen-driven PI3K/AKT dysregulation exemplifies its carcinogenic potential: oncogenic HPV elevates p-AKT (Ser473) or p-Src (Tyr527) to initiate cervical carcinogenesis.248 Therapeutically, mTOR inhibition extends lifespan across preclinical models,250 highlighting its dual role in aging-associated precancer control and longevity regulation.