The Hippo pathway functions as a central regulator of tissue homeostasis, coordinating a conserved kinase cascade from the tumor suppressors MST1/2 to the oncoproteins YAP/TAZ to balance cell proliferation and apoptosis.311 While Hippo pathway dysregulation induces YAP/TAZ-driven overexpression of prosurvival genes (e.g., c-MYC and survivin) and tumorigenesis in model organisms,312,313 human cancers rarely exhibit Hippo gene mutations, suggesting that the oncogenic role of the Hippo pathway is predominantly driven by microenvironmental dysregulation. Here, YAP1 is linked to neoplasm.