Although there are reports of the isolation of several subclasses of alkaloids, such as oxoaporphine, aporphine, 4‐Azafluorenone, bisaporphine, and benzil‐tetrahydro‐isoquinoline alkaloids, only the Aristolactams subclass was tested for inhibition of DYRK1A and CDK1/cyclin B, associated with neurodegenerative diseases. Here, DYRK1A is linked to neurodegenerative disease.