Input-CDK8 and input-MED12 levels did not differ significantly between the groups, but the amount of CDK8 bound to MED12 (IP-CDK8) and IP-MED12 were significantly greater in MED12 MUT leiomyomas treated with GnRH agonist (Fig 1C–F). The gene discussed is CDK8; the disease is leiomyoma.