APOE and dementia: Some research has suggested that lipid levels of APOE4 carriers are most susceptible to dietary changes and so lifestyle modification may also represent an avenue of dementia risk reduction, notwithstanding the inconclusiveness of the available evidence concerning the use of LLT pharmaceuticals.47 As the practice of medicine becomes more personalized, understanding the interaction between cardiovascular risk factors and genotype may lay the ground for targeted programs to reduce future risk of dementia starting much earlier in the lifespan.