As such, it is possible that a similar relationship between duration of uncorrected lipid abnormality and dementia may exist, but available data are inconclusive at this point.41, , –44 Population studies have shown that LLT is effective in mitigating APOE4 associated risk independent of cholesterol levels,45 suggesting a tentative relationship between LLT use and dementia risk in the context of limited evidence. Here, APOE is linked to dementia.