APOE and early-onset autosomal dominant Alzheimer disease: Recent studies have proposed that one possible mechanism by which APOE4/4 is linked to increased risk for Alzheimer's disease may be due to its effects in LD dynamics in astrocytes and microglia that ultimately contribute to exacerbated lipid peroxidation and inflammation (Haney et al. 2024; Windham et al. 2024).