Of particular interest, we observed downregulation enrichment in Complement and Coagulation Cascades (Figure S1H, p < 0.001) and Rheumatoid Arthritis-related pathways (Figure S1I, p = 0.032), indicating Metrnl’s multifaceted involvement in both innate immune regulation and potential modulation of hemostatic processes. The gene discussed is METRNL; the disease is rheumatoid arthritis.