Notably, the glycolysis-relatedgenes ALDOA, PGK1, and ENO2previously shown to be upregulatedin HCC tumors (Figure )were inversely correlated with γδ T cell infiltration(Spearman’s r = −0.24, FDR = 3.9e–05; Figure G), implicating glycolyticreprogramming as a barrier to effective immune infiltration. The gene discussed is ALDOA; the disease is hepatocellular carcinoma.