TNFSF10 and neoplasm: By exploiting the acidic tumor microenvironment, the nanogelundergoes controlled destabilization to facilitate localized GOx release,leading to sustained oxidative stress and glycolytic deprivation.This metabolic interference sensitizes tumor cells to apoptosis andsignificantly enhances the therapeutic efficacy of codelivered agentssuch as TRAIL and DOX by simultaneously activating intrinsic and extrinsicapoptotic pathways.