PDCD1 and neoplasm: Transcriptomic profiling confirms thatthis nanozyme remodels the immunosuppressive microenvironment by suppressingmetabolic pathways while activating immune-related gene programs.When combined with an anti–PD-1 checkpoint blockade, the nanozymeelicits potent tumor regression and abrogates metastasis without systemictoxicity in orthotopic HCC models.