In a BMDC-splenocyte-HCC co-culture system(Figure M), GOx-DOX-LGPsignificantly enhanced dendritic cell maturation (CD86+ MHC-II+ in CD11c+) and CD8+ T-cellactivation and proliferation, as evidenced by increased granzyme Band Ki67 expression (Figure N), culminating in enhanced tumor cell lysis (Figure O). This evidence concerns the gene MKI67 and neoplasm.