The current result was in agreement with a report that BDNF treatment alleviated alcohol‐withdrawal anxiety in mice and normalized neurons [53], and another report that the habenula BDNF/TrkB/CREB cascade was reduced and normalized by acupuncture using a rat depression model [54], suggesting endogenous BDNF signaling stabilizes mood via neuroplasticity [55]. This evidence concerns the gene NTRK2 and major depressive disorder.