These proteins interact with E-box-containing DNA promoters, facilitating cancer cell invasiveness and metastasis in several malignancies.13, 14, 15, 16 Within the large Snail-centered EMT network, E3 ligases, such as FBXW1,17 FBXL5,18 FBXO11,19 and TRIM21,20 interact with Snail and regulate tumor cell invasion metastasis and proliferation. Here, SNAI1 is linked to cancer.