Compared with the κ-ORfl/fl + control group, the κ-ORfl/fl + HPH group presented increased right ventricular pressure, pulmonary vascular remodeling, and right ventricular hypertrophy and dysfunction; infiltration of M1 macrophages around pulmonary vessels; increased NLRP3 protein expression; and the release of the inflammatory cytokines. This evidence concerns the gene NLRP3 and Right ventricular hypertrophy.