Notably, a core signature comprising seven genes, including small nuclear ribonucleoprotein polypeptide F (SNRPF), replication factor C subunit 3 (RFC3), WD repeat domain 75 (WDR75), RAD51 recombinase (RAD51), CDC20, DTL, and RRM2, showed a strong correlation across multiple prostate cancer cohorts at different progression stages. Here, RFC3 is linked to Familial prostate cancer.