The combination of 2‐deoxy‐d‐glucose (glycolysis inhibitors) and sorafenib (multikinase TKI, which inhibits CRAF, BRAF, VEGFR‐2, VEGFR‐3, PDGFR‐β, Flt3, c‐Kit, and p38α67) significantly suppresses the tumor growth of patient‐derived xenografts of NRASQ61 melanoma [344]. This evidence concerns the gene RAF1 and melanoma.