These genes represent coordinated axes of T‐cell dysfunction in sepsis, including dysregulated inflammatory/innate signaling (IL1R2, LTB, PRKCA, MARCO, SLC11A1, RNF10, and COMMD6), mitochondrial and bioenergetic stress programs (COX7B, PPM1K, IER5, WHAMM, and NUCKS1), and impaired trafficking and activation signaling (S1PR1, TESPA1, and CD96). This evidence concerns the gene IER5 and Sepsis.