PNPLA3 and hepatocellular carcinoma: Although evidence for PRS generally comes from cohort studies, genetic variants can be integrated with EHR-linked data to contribute to risk stratification, in projects such as Genes and Health, FinnGen and UK Biobank (UKBB).66, 67, 68 For example, a study pooling multiple databases with EHR-diagnosis found that a set of genes including PNPLA3 is associated with more severe steatohepatitis and fibrosis, and individuals in the top 10% of PRS have a 2.5-fold and 2.9-fold increased odds of cirrhosis (95% CI: 2.0–3.2), and HCC (95% CI: 1.8–4.8) compared to those with PRS in the bottom decile.69