PNPLA3 and fibrosis: Specifically, studies have reported mediating effects of genetic risk variants (evidence for PNPLA3 > polygenic risk scores > TM6SF2 > other risk variants) and BMI, alcohol and T2DM on transaminase levels, hepatic steatosis, fibrosis/cirrhosis or liver-related outcomes in population-based[13], [14], [15], [16], [17], [18], [19], [20], [21], [22] and liver-biopsy cohorts.23