Hypomorphic variants have best been studied in IRDs in the context of ABCA4-associated Stargardt disease.23, 24, 25 When evaluating the discordant designations with AlphaMissese in ABCA4, we found that of the 9 well-characterized hypomorphic variants (Table 3), AlphaMissense only correctly scored one of them, the well-established Gly1961Glu variant,26 as likely pathogenic. The gene discussed is ABCA4; the disease is Stargardt disease.