TRIM21 and obesity due to melanocortin 4 receptor deficiency: The study also proposed the use of red blood cell exosomes loaded with Trim21 antisense oligonucleotides to target macrophage TRIM21, inhibiting obesity-induced inflammation and associated metabolic disorders [53]. Moreover, neddylated cullin 3 (Cul3) plays a significant role in both adipogenesis and hepatocellular carcinoma.