SLC5A2 and endothelial dysfunction: Furthermore, the hyperglycemic state can lead to a series of microvascular and macrovascular complications [9], such as endothelial dysfunction [10], advanced glycation end-product formation [11], hypercoagulability, increased platelet reactivity, and upregulation of sodium-glucose cotransporter-2 (SGLT-2) [12], which are also key targets for diabetes treatment.