To uncover convergent transcriptional processes in acute myeloid leukaemia (AML), we analysed differentially expressed genes (DEGs) across four perturbation models: PSPC1 knockdown, JMJD1C knockdown, RUNX1 knockdown, and venetoclax in conjunction with cysteine starvation (VEN + CSA). Here, RUNX1 is linked to acute myeloid leukemia.