To evaluate the generalizability of this signature, we examined an independent RNA‐seq dataset (GSE229032) consisting of 73 samples from 15 other AML cell lines, including MOLM‐13, MV411, OCIAML4, HL60VCR, KG1, THP1, KASUMI1, SET2, and U937. Here, SETD2 is linked to acute myeloid leukemia.