RUNX1 and acute myeloid leukemia: JMJD1C, a histone demethylase, facilitates the preservation of leukaemic stem cells via epigenetic regulation, whereas RUNX1, a principal regulator of haematopoiesis, often displays mutations or dysregulation in acute myeloid leukaemia that hinder differentiation and lineage fidelity [16, 17, 18].