An enhancement in cellular internalization was observed in response to CD44 receptors, followed by GSH‐triggered camptothecin release in response to laser‐induced ROS production in hypoxic condition. A significant downregulation of Bcl‐2 and elevation of cleaved caspases was observed, initiating STING pathway, and suppression of tumour growth was observed. The histopathological examination of 4T1 mouse tissues augmented tumour necrosis while preserving structural integrity of organs. This evidence concerns the gene BCL2 and neoplasm.