DDR1 and glioblastoma: Similarly, in glioblastoma combined inhibition of DDR1 and intαVβ3/αVβ5 using DDR1-IN-1 and cilengitide impaired DNA double-strand break (DSB) repair by altering Ataxia-Telangiectasia Mutated protein kinase (ATM) and DNA-dependent protein kinase (DNA-PK) phosphorylation, radiosensitized tumors and correlated with worse patient survival [126].