C5 and paroxysmal nocturnal hemoglobinuria: 7 Additionally, C5a induces neutrophil tissue factors expression,39 and monocyte extracellular vesicles further promote coagulation40. PNH also has fibrinolytic defects, possibly linked to the deficiency of fibrinolysis‐related GPI/GPI‐APs 41, 42 and the release of fibrinolysis‐inhibiting substances by activated platelets/neutrophils. 43 Complement and coagulation cascades cooperate, ultimately causing pathological thrombosis in PNH patients.7