CAPN3 and neurodevelopmental disorder with hypotonia, brain anomalies, distinctive facies, and absent language: The disease had been added a part of routine curation of new data in the published literature into the SimulConsult database and RNU4-2 was listed as #1 in usefulness of further genetic testing based on the strong clinical match with ReNU syndrome, similar to that for CAPN3 in Fig. 2.