Neuroendocrine pathways regulate this axis; mineralocorticoid receptor (MR) activation in hepatocytes modulates cardiac repair post-MI via fibroblast growth factor 21 (FGF21), whereas an upstream IL-6–STAT3 pathway suppresses MR expression, increasing cardioprotection—a dynamic liver–to-heart feedback loop.251. This evidence concerns the gene NR3C2 and myocardial infarction.