EPHX2 and Alzheimer disease: Additionally, signaling factors such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and cytokines, as well as other metabolites, circulate to the brain and modulate neural activity.98,99 The activity of hepatic soluble epoxide hydrolase (sEH) influences cerebral Aβ metabolism and AD pathogenesis.32,100,101 Modifying the liver–brain interaction in response to environmental stimuli holds potential as a therapy to prevent AD.