PTEN and neoplasm: For example, deletion of the tumour suppressor LKB1/STK11 promotes the accumulation of pro‐tumour TANs and confers resistance to ICIs in lung cancer,117, 118 while loss of PTEN drives excessive PI3K‐AKT signalling activation, inducing expression of immunosuppressive cytokines that enhance TAN accumulation and reduce T cell recruitment in tumours.119