The coculture of MSC/CAF and GBM affects the expression of several genes, such as CXCL5 and COL16A, which are associated with invasiveness, tumorigenesis, and angiogenesis, and TREM-1, which is known amplify innate immune/inflammatory responses, and correlates with worse overall survival (OS) and progression-free survival (PFS) in GBM. This evidence concerns the gene TREM1 and glioblastoma.