CD274 and non-small cell lung carcinoma: We collected digitized H&E slides, clinical data and outcomes for 148 patients with advanced NSCLC treated with ICIs against programmed death-1 protein (PD-1) or programmed death ligand 1 (PD-L1).HEX was used to generate virtual CODEX maps from the H&E images, which were then integrated with histology features for outcome prediction in our MICA framework.