MGMT and glioblastoma: In a multivariate analysis accounting for gender, age, canonical GBM subtypes defined based on interpatient transcriptomic heterogeneity, MGMT methylation status and treatment (chemoradiation vs radiation alone); M-H versus M-La or M-Lb independently predicted shorter survivals (log-rank p = 3.0e-3 and 2.7e-13, respectively; Supplementary Table 3).