INS and obesity due to melanocortin 4 receptor deficiency: A similar pattern emerged for obesity-related cancers: surgery was associated with lower rates in the two highest insulin thirds (HRadj = 0.52; 95% CI [0.37, 0.73]; p < 0.001, and HRadj = 0.66; 95% CI [0.49, 0.88]; p = 0.006) (Fig 3B).