Indeed, proinflammatory cytokines and chemokines downstream of IFN-induced signaling, such as IL-6, IL-22, MCP-1 (CCL2), TNF-α, and VEGF-A, are upregulated in plasma from individuals with DS, consistent with a hyperactivated IFN paradigm [21,22]. The gene discussed is VEGFA; the disease is Dravet syndrome.