Following the same strategy as for monocytes, we found that “metabolic glycolysis senescence”, “pathway apoptosis caspase”, processing degradation regulation”, antiviral interferon-gamma”, “translation SARS infections”, among many other pathways (Fig 3a and S5 Table) associated with inflammatory responses against pathogens and protein translation upregulated in T cells from individuals with DS. This evidence concerns the gene IFNG and infection.