Consistently, increased levels of T-cell-related cytokines (IL-2, MIP-1α, MIP-3α, IL-10, Eotaxin, IL-8, IL-17A–D, and IL-22) have been found in plasma of individuals with DS [18]; among them IL-10 and IL-8 are upregulated in severe COVID-19 [36]. This evidence concerns the gene CXCL8 and COVID-19.