Strikingly, loss of accessibility in mucociliary gene-associated (MCE) peaks was significantly higher than in the rest of the genome (Fig 2E), increasing from 53.7% lost non-MCE peaks to 57.7% lost BC-associated peaks, to 58.4% lost ISC-associated peaks, and to 58.5% lost MCC-associated peaks (Fig 2F), and Fox-factor motifs were enriched in the MCE fraction of peaks that lost accessibility after foxi1 MO (S4 Data). Here, FOXI1 is linked to breast cancer.