TMEM106B and amyotrophic lateral sclerosis: We also examined associations of two other RNA targets with 3′ UTR lengthening previously identified in TDP-43 knockdown iNeurons: the splicing factor proline and glutamine rich (SFPQ), an RNA binding protein associated with the pathogenesis of FTLD-TDP and ALS, and the lysosomal transmembrane protein 106B (TMEM106B), a known genetic risk factor for FTLD-TDP confirmed to exhibit 3′ UTR lengthening in the FTLD-TDP brain [12,40–43].