TARDBP and amyotrophic lateral sclerosis: Endolysosomal impairment is widely implicated in TDP-43 proteinopathies, including AD, FTD/ALS, and Parkinson’s disease [57–59], and our prior studies established a role for endolysosomal dysfunction in inducing TDP-43 proteinopathy in FTD/ALS [60].