In the early phases of thyroid oncogenesis, BRAF p.V600E or RET/PTC oncogenes drive the expression of HIF1α (85), although the concomitant overexpression of c-MYC, belonging to the same signaling pathway, quickly overturns HIF1α regulation by suppressing BGLT3 transcription at its locus (86). This evidence concerns the gene HIF1A and thyroiditis.