Pellecchia et al. showed that MPPED2-AS1 and MPPED2 are both significantly downregulated in benign and malignant thyroid neoplasms, including well-differentiated and undifferentiated thyroid carcinomas, proving to be strongly positively correlated with each other (93). This evidence concerns the gene MPPED2 and thyroid gland undifferentiated (anaplastic) carcinoma.