Total RIF1 mRNA expression was significantly downregulated in breast invasive carcinoma (BRCA) relative to the matched normal breast tissue, while RIF1 expression levels were relatively upregulated in colon adenocarcinoma (COAD), lung adenocarcinoma (LUAD), and lung squamous carcinoma (LUSC) (Fig. 2B). Here, RIF1 is linked to lung adenocarcinoma.