For example, application of this technology to study idiopathic pulmonary fibrosis (IPF)—a lung disease characterized by dysregulated ECM turnover—identified aberrant basal-like cells, peribronchiolar endothelial cells, SPP1+ macrophages, and myofibroblasts as key drivers of pulmonary tissue remodeling, suggesting new strategies to combat the disease (Adams et al., 2020). The gene discussed is SPP1; the disease is pulmonary fibrosis.