Moreover, these two subsets were co-inducible by a standard skin challenge of TB patients with M.tb-derived antigen (tuberculin), and analyses of spatial transcriptomics data from an independent cohort of TB patients showed colocalization of both this myofibroblast signature and the SPP1+ macrophage signal within lung TB granuloma cuffs. This evidence concerns the gene SPP1 and pulmonary tuberculosis.