MMP9 is a proteinase involved in the degradation of ECM that is strongly associated with TB granuloma (Rohlwink et al., 2019); CST7 (cystatin F) is a neutrophil marker of acute inflammation (Huang et al., 2021); and, LDHA encodes lactate dehydrogenase, which enhances neutrophil migration and activity, and is highly elevated in hypoxic lung TB granuloma in animals (Chowdhury et al., 2022; Krishnamoorthy et al., 2020). This evidence concerns the gene MMP9 and tuberculosis.