Further to this, SARS‐CoV‐2 spike protein (S‐protein) was found to prime inflammasome formation and release of mature IL‐1β in macrophages derived from COVID‐19 patients but not in macrophages from healthy SARS‐CoV‐2 naïve individuals, which correlated with distinct epigenetic and gene expression signatures suggesting innate immune memory after recovery from COVID‐19 [129]. The gene discussed is IL1B; the disease is COVID-19.