Indeed, the central roles of SYK and KMT5A in trained immunity have previously been highlighted: heme‐induced training induces SYK phosphorylation in human monocytes [46], while elevated KMT5A expression was observed in blood monocytes from unstable angina patients with hsCRP ≥ 3 mg/L and evidence of trained immunity [9]. The gene discussed is KMT5A; the disease is angina pectoris.