Indeed, plasma S100A8/S100A9 correlates with leukocyte counts and coronary artery disease (CAD) in type 1 diabetes (T1D) [60], suggesting that targeting of the S100A8/S100A9‐RAGE axis may reduce atherosclerosis and cardiovascular events in diabetic individuals with adequate glycaemic control. This evidence concerns the gene AGER and coronary artery disorder.