Aside from clinical evidence, several Mendelian randomization analyses have been performed to verify the causal link between LDL-C and risk of CAD [37], the causal link between BMI and T2D [38], and the causal link between BMI and CAD [39], including analyses based on variants in the HMGCR locus [19]. This evidence concerns the gene HMGCR and type 2 diabetes mellitus.