In summary, we found consistent evidence in the HMGCR gene region to validate LDL-C as a causal risk factor for CAD, and BMI as a causal risk factor for T2D, and inconsistent evidence for BMI as a causal risk factor for CAD, and LDL-C as a causal risk factor for T2D. The gene discussed is HMGCR; the disease is coronary artery disorder.