ANXA2 and cardiofacioneurodevelopmental syndrome: CCDC32 was identified through genetic studies, originally in a yeast 2-hybrid screen for proteins interacting with annexin A2 (Li et al., 2011) and subsequently via whole exome sequencing to identify mutations associated with cranio-facio-neurodevelopmental syndrome (CFNDS) (Abdalla et al., 2022; Harel et al., 2020), neither of which provided insight into its cellular function.