LMNA and Hutchinson-Gilford progeria syndrome: These DEGs were compared with the 693 genes consistently up- or down-regulated in HGPS patient samples (Figure 2(C)) and we identified a total of 148 differentially expressed genes between all primary cell lines and GFP-progerin induced cells, of which 85 genes were upregulated, and 63 downregulated in both GFP-progerin and HGPS patient cell lines (Figure 4(B)).