Importantly, the most prominent HGPS pathways, including mTORC1, Notch signaling, andthe UPR, as well as pathways involved in myogenesis, oxidative phosphorylation, apoptosis, inflammatory response, ROS production, DNA repair, and angiogenesis were upregulated in 80–100% of HGPS patients (Figure 3(E), Figure S3(B)). This evidence concerns the gene ZMPSTE24 and Hutchinson-Gilford progeria syndrome.