LMNA and Hutchinson-Gilford progeria syndrome: To understand how well HGPS cellular models recapitulate the disease, we compared the transcriptional status of all 16 primary patient skinfibroblast samples to a well-characterized GFP-progerin inducible skin fibroblast cell line after 6 days of induction, which recapitulates many of the most prominent hallmarks of HGPS patient cells, including altered nuclear morphology, epigenetic marks, and increased DNA damage [40] (Figure S4(A)).