To further explore potential mechanisms underlying long‐term cognitive impairment in patients with anti‐NMDAR encephalitis, we assessed hippocampal neurogenesis, as previous studies have shown that CHI3L1 can impair neural stem cell (NSC) differentiation through CRTH2‐mediated suppression of β‐catenin signaling [19, 28]. This evidence concerns the gene PTGDR2 and Cognitive impairment.