In multivariable logistic models, serum CHI3L1 (OR: 2.57, 95% CI 1.38–5.47, p = 0.006; Table S3) and CSF CHI3L1 (OR: 4.28, 95% CI 1.97–11.49, p = 0.001; Table S4) levels remained independently associated with cognitive impairment. This evidence concerns the gene CHI3L1 and Cognitive impairment.